CRISPR-GPT is an advanced AI co-pilot leveraging large language models (LLMs) to streamline gene-editing workflows, supporting four major modalities across 22 specific tasks. It operates in three modes: Meta, Auto, and Q&A, catering to users from novice to expert levels. In Meta mode, the AI guides beginners through the gene-editing process, from CRISPR system selection to protocols and data analysis. Auto mode allows advanced users to submit customizable requests, automating task management and execution.
CRISPR-GPT has been tested and proven effective in real-world labs, guiding researchers unfamiliar with gene editing through complex experiments, resulting in successful gene knockouts and epigenetic activations with high editing efficiencies. Its multi-agent architecture incorporates expert knowledge, automating task planning, delivery method selection, and gRNA design, while the Q&A mode enhances troubleshooting capabilities. Human evaluations confirm that CRISPR-GPT outperforms general-purpose LLMs in accuracy and relevance, demonstrating its potential in accelerating biological research efficiently.
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