George Kumar, Senior Director at AstraZeneca, highlights groundbreaking research from the Virginia Commonwealth University School of Medicine. Their new AI tool, Vesalius, innovatively maps tumor cells’ spatial arrangements and gene activity, revealing how cancer cells communicate with their neighbors. This pioneering computational tool provides a multi-scale, interpretable approach to understanding tissue architecture at a molecular level, named after the revolutionary anatomist Andreas Vesalius. The significance of Vesalius lies in its ability to differentiate between therapy responders and non-responders by decoding spatial tissue patterns, identifying critical subpopulations of tumor and immune cells that contribute to treatment resistance. This development is set to transform cancer diagnostics, facilitate the discovery of predictive biomarkers, and lead to personalized therapy strategies. The comprehensive overview of Vesalius underscores its potential impact on cancer biology and patient care. For further details, refer to the full article.
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