Researchers are investigating how gene alterations impact gene activity using CRISPR and a technique called Perturb-seq. This approach allows scientists to manipulate individual or multiple genes and subsequently analyze RNA changes in cells. When a gene is altered, its messenger RNA may change, potentially affecting numerous other genes—especially if the altered gene regulates others. Interactions between multiple genes can lead to simple additive effects or more complex interactions, producing unexpected outcomes. The study involves training foundation models to predict these changes based on data from experiments that activated one or two genes. Researchers compared the AI’s predictions against simple models that assumed either no change or purely additive effects. This innovative research aims to enhance the understanding of gene regulation and could lead to breakthroughs in genetics and biotechnology. For effective SEO, focus on keywords like “gene activity,” “CRISPR,” “Perturb-seq,” “gene regulation,” and “AI predictions.”
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