Artificial intelligence (AI) is poised to revolutionize urology, enhancing everything from student education to clinical procedures and reporting. This focus issue highlights various applications of AI within the field, reflecting growing enthusiasm from the medical community. The World Health Organization’s 2024 strategic document emphasizes safe, ethical, and equitable AI adoption in healthcare, while the 2025 FUTURE-AI framework outlines trustworthy AI development guidelines. The recent surge in AI studies at international urological conferences illustrates the transformative potential of AI technologies. With contributions covering diverse topics—including digital twins for personalized treatment in uro-oncology and large language models (LLMs) in medical education—this compilation sheds light on the extensive opportunities presented by AI. Moreover, it discusses critical elements such as ethical considerations and cutting-edge advancements in prostate cancer diagnostics. Overall, the integration of AI in urology not only offers innovative solutions but also reinforces the importance of responsible deployment in the healthcare landscape.
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